GW28-e0424 NOTCH1 contributes to cardiac inflammation and fibrosis by facilitating Smad2/3 and NF-κB signaling pathway in hypertension

The molecular mechanism underlying angiotensin II-induced cardiovascular injury remains to be defined. The present study was undertaken to determine the role of NOTCH1 in the process of angiotensin II-induced cardiac remodeling in vivo. We compared the in vivo effects of 4 weeks of subcutaneous