Biosynthesis of Tetronasin. Part 5. Novel Fluorinated and Non- Fluorinated Analogues of Tetronasin via Intact Incorporation of Di-, Tri- and Tetraketide Analogue Precursors.

Abstract Incorporation experiments with both fluorine-labelled and unlabelled N-acetylcysteamine analogues ( 6 ), ( 7 ), ( 8 ), ( 9 ), ( 11 ), ( 13 ), ( 14 ) and ( 17 ) of the proposed di-, tri- and tetraketide precursors showed that the acyl residues are incorporated intact into tetronasin ( 1 ). Equivalent experiments with N-acetylcysteamine analogues ( 12 ), ( 15 ), ( 16 ) and ( 18 ) resulted in no detected intact incorporation into ( 1 ).