Association of ovarian response with picoAMH in women undergoing controlled ovarian hyperstimulation.

Abstract Objective Our study aims to evaluate the diagnostic performance of a high-sensitivity picoAnti-Mullerian Hormone (picoAMH) for predicting ovarian response in women undergoing controlled ovarian hyperstimulation and occurrence of ovarian hyperstimulation syndrome. Methods Retrospective cohort study at a single academic fertility center including all patients with picoAMH ELISA who underwent controlled ovarian hyperstimulation. The primary outcome was the number of oocytes retrieved, and secondary outcomes included cycle cancellation and ovarian hyperstimulation syndrome. Patients were grouped into poor, normal, and hyper-responders based on number of oocytes retrieved. Results The mean AMH and antral follicle count (AFC) were significantly different between normal response vs. hyper response group (p Conclusion This study shows great utility of picoAMH ELISA for predicting ovarian response to controlled ovarian hyperstimulation (COH). Diagnostic performance of picoAMH for prediction of OHSS is superior to the AFC in our cohort.