Formulation, Evaluation and Characterization of Metformin Hydrochloride and Glimepiride in Sustain Release Bilayer Dosage Form

The Aim of this research work was to develop sustained release bilayer dosage form by using Metformin Hydrochloride and Glimepiride that can help to provide synergistic effect for the therapeutic management of Diabetes. Bilayer dosages form was developed and determines the sustained release effect of both Metformin Hydrochloride and Glimepiride by using various polymers as MCC PH 102, Starch paste, Ethyl cellulose, Eudragit RLPO etc. at different concentration. As tested by FTIR the excipients cast-off in this research did not modify physicochemical properties of the drug. Formulated batches were assessed for thickness, weight variation, hardness and drug content uniformity. USP apparatus II was used for in vitro drug dissolution study which utilize paddle and the release mechanisms were discovered. From in-vitro dissolution study it was concluded that the formulation F2 was shown highest drug release taken optimized formulation. Release kinetic models were applied on release data and it was found that drug followed Higuchi’s release kinetic model.