Transcutaneous blood glucose monitoring for diabetics using an ISFET glucose sensor

Transcutaneous blood glucose monitoring using an ISFET glucose sensor, was successfully achieved for five diabetic patients. This system consists of a Suction Effusion Huid (SEF) collecting unit, an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a control unit. The SEF was collected by a 400 mmHg absolute pressure, applied to the skin surface during 75g oral glucose loading. The glucose concentrations in 5 μ1 SEF were measured by an ISFET glucose sensor, compared with blood glucose changes. SEF glucose changes faithfully followed blood glucose changes with a few minutes delay. Frequent blood glucose monitoring were transcutaneously realized for individual patients with various diabetic histories or diabetic complications.