P661 Evaluation of childhood urinary tract infection and antibiotic susceptibility in a turkish center

Introduction Urinary tract infection (UTI) is the most common bacterial infection in children under 2 years of age. Proper and timely treatment protects patients from long-term complications such as renal scarring, hypertension, and end-stage renal disease. Methods The file records of 729 patients aged between 0–18 years, followed up with diagnosis of urinary tract infection, vesicoureteral reflux and neurogenic bladder in Ege University Pediatric Nephrology Unit between February 2013 and November 2018 were retrospectively reviewed. Results A total of 1126 positive urine cultures of 729 patients (65% female/35% male) were included in the study. The mean infection time was 56 ± 53 months. Most of the cultures (88.2%) were gram negative. Escherichia coli (E. coli) was the most common isolated bacteria with a prevalence of 59.1% (n= 666) followed by Klebsiella pneumonia with 17.9% (n= 202), Enterococcus faecalis 8.3% (n= 93), Proteus mirabilis 3.2% (n= 37), Enterococcus faecium 2.9% (n= 33) and Pseudomonas aeruginosa 2.5% (n= 28). Enterobacteriaceae in 962 cultures (85.4%) constitute most bacteria in this study. Ampicillin, cefuroxime and trimethoprim-sulfamethoxazole with susceptibility rates of 18.6%, 39.6%, 49.0% respectively, constitute of the highest resistant antimicrobials to Enterobacteriaceae. Antimicrobials with the highest susceptibility in this group were meropenem, imipenem and ertapenem with susceptibility rates of 99.2%, 97.1% and 96.1% respectively. Enterococcus spp. showed the highest resistance to gentamycin with 50% resistance to tested cases. Pseudomonas spp. with 64.3% susceptibility, showed the highest resistance to piperacillin-tazobactam. Conclusion Enteric bacteria, majority of which constituted by E.Coli are at the forefront in the etiology of UTI. Diagnosis and accurate treatment of the disease prevents or reduces late complications and morbidity. Determination of local antibiotic susceptibility patterns, that expected differ by region and time, has a great importance for initiating effective empirical treatment and prevent complications.