FUT2 non-secretor status is associated with Type 1 diabetes susceptibility in Japanese children
2017
Aim
To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children.
Methods
We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined.
Results
The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20–2.35); corrected P value = 0.0075].
Conclusions
The FUT2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.
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