Взаимосвязь некоторых иммунологических и биохимических показателей в синовиальной жидкости больных дегенеративно-дистрофическими поражениями суставов

We studied the synovial fluid of healthy subjects and individuals with advanced OA of various etiology in order to reveal the biological changes in the levels of total protein, protein fractions and immunoglobulins A, M, G and their interrelationship. In the SF from the joints with advanced OA, the total protein rose significantly and its fractions redistributed. We also revealed significantly high concentrations of IgA, IgM, and IgG in them that depended on the etiology as the highest values were detected in aseptic necrosis of the femoral head. There was a strong correlation between all classes of immunoglobulins A and β-globulins and a strong correlation between the total protein and IgM and, as well as between IgM and βor γ-globulins.