Accurately characterized optical tissue phantoms: how, why and when?
2011
Optical tissue phantoms are very important tools for the development of biomedical imaging applications. Optical
phantoms are often used as ground truth against which instruments results can be compared. It is therefore important that
the optical properties of reference phantoms be measured in a manner that is traceable to the international system of
units. SI traceability insures long term consistency of results and will therefore improve the effectiveness of diffuse
optics research effort more effective by reducing unwanted variability in the data produced and shared by the
community. The ultimate benefit of rigorous SI traceability is the reduction of variability in the data produced by novel
diagnostic devices, which will in turn increase the statistical power of clinical trials aiming at validating their clinical
usefulness. SI traceability, and therefore uncertainty analysis, is also relevant to traceability aspects mandated by FDA
regulations. SI traceability is achieved through a thorough analysis of the measurement principle and its potential error
sources. The uncertainty analysis should be ultimately validated by inter-laboratory comparison until a consensus is
attained on the best practices for measuring the optical properties of tissue phantoms.
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