Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

Julien Ratelade,Nicholas R. Klug,Damiano Lombardi,Monara Kaélle Sérvulo Cruz Angelim,Fabrice Dabertrand,Valérie Domenga-Denier,Rustam Al-Shahi Salman,Colin Smith,Jean-Frédéric Gerbeau,Mark Nelson,Anne Joutel

Reducing Hypermuscularization of the Transitional Segment between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage

2020

Julien Ratelade
Nicholas R. Klug
Damiano Lombardi
Monara Kaélle Sérvulo Cruz Angelim
Fabrice Dabertrand
Valérie Domenga-Denier
Rustam Al-Shahi Salman
Colin Smith
Jean-Frédéric Gerbeau
Mark Nelson
Anne Joutel

Background: Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the sit...

Keywords:

Stroke
smooth muscle
Diabetes mellitus
Medicine
spontaneous intracerebral hemorrhage
Cardiology
Intracerebral hemorrhage
Internal medicine
Hyperplasia
Contractility
Arteriole
Downregulation and upregulation
Mural cell
Retina
genetic model
Pathology

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