The chromatin-binding protein Smyd1 restricts adult mammalian heart growth
2016
This study is the first to demonstrate that loss of a muscle-specific chromatin-binding protein, Smyd1, is sufficient to induce cardiac hypertrophy and failure. Moreover, the findings demonstrate that augmentation of Smyd1 levels can block hypertrophy in cell models. These studies may support novel strategies for cardiac-targeted epigenetic therapy.
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