Original Communication Loss of sex chromosome in acute myeloid leukemia

chromosome also occurs with advancing age. 6 The frequency of loss of Y chromosome in males with no evidence of hematological disease has been reported to be 7.7%. 7 Cells with - Y are observed more often in males over age 55 than in younger males. The frequency of - Y cells increases with advancing age and is significantly greater in case with MDS, MPD, ANLL, or LPD than in subjects with no evidence of disease, the later rarely exhibit more than 75% of cells with 45, X, -Y. Specific chromosomal abnormalities are well recognized in acute leukemia, and are emerging as major determinants for treatment, response and survival. 8,9 Loss of Y chromosome as a sole abnormality or with additional cytogenetic changes has been reported in acute myelogenous leukemia (AML), although it is not clear whether or not this abnormality is a marker for the