Synthesis of a new alkynylated deoxyadenosine phosphoramidite for the click reaction-mediated DNA labeling
2019
A new 5′-dimethoxytrityl N6-alkynylated 2′-deoxyadenosine phosphoramidite has been designed and synthesized from 2′-deoxyadenosine. The applicability of this building block for the production of alkyne-modified oligodeoxynucleotide has been demonstrated. This allows one to introduce various labels into DNA using the click reaction.
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