Complete Stereocontrol in the Synthesis of Harmonine and Novel Analogues Facilitated by a Grubbs Z-Selective Cross-Metathesis Catalyst
2015
( R )-Harmonine was synthesised in 15 % overall yield via a six-step sequence exploiting a Z -selective cross-metathesis reaction as its centrepiece. By this strategy, the cis -olefin present in the target could be installed exclusively. The use of an alcohol and an ester as the amine precursors was crucial for isolating the cross-metathesis product from the self-metathesis products. This method was also used to prepare two novel analogues of harmonine.
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