Exercise Mimetic Pills for Chronic Diseases Based on Autophagy

Noncommunicable chronic diseases such as metabolic diseases including obesity and diabetes, and cardiovascular diseases including ischemic heart disease have high incidence not only in developed countries, but also in developing countries. Lack of physical activity increases a major risk factor for many chronic diseases such as cardiovascular diseases and diabetes, which is close to the effect of smoking. Physical inactivity causes approximately 9% of premature deaths, especially causing some noncommunicable diseases [1]. The effect of physical inactivity on the triggering of chronic diseases has also been confirmed, especially for fatty liver [2], sarcopenia [3], Alzheimer’s disease, and diabetes [4], which is mainly due to the deficiency of autophagy from physical inactivity.