Present and future frameworks of theoretical neuroscience: outcomes of a community discussion.

We organized a workshop on the "Present and Future Frameworks of Theoretical Neuroscience", with the support of the National Science Foundation. The objective was to identify the challenges and strategies that this field will need to tackle in order to incorporate vast and multi-scale streams of experimental data from the technologies developed by the BRAIN initiative. The participants, divided in workgroups, identified five key areas that, while not exhaustive, cover multiple aspects of current challenges needed to be developed: Dynamics-statistics; multi-scale integration; coding; brain-body integration; and structure of neuroscience theories. While each area is different, there were coincidences on finding theoretical paths to incorporate biophysics, energetics, and ethology with more abstract coding and computational approaches. Each workgroup has continued to work after the meeting to develop the ideas seeded there, which are started to being published. Here, we provide a perspective of the discussions of each workgroup that point to building on the present foundations of theoretical neuroscience and extend them by incorporating multi-scale information with the objective of providing mechanistic insights into the nervous system.