Altered Host Resistance to Listeria monocytogenes In Mice Exposed to 1—Chloroacetophenone（CN）Vapours

Short term repeated exposure of 1-chloroacetophenone(CN)vapours at a concentration of 0.153mg per litre for 15 minutes daily on 10 consecuitve days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes.Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals.The increasd bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals.Increased susceptibility of infection has been considered to be the function of immune alteration due to cumulative short term effects of Cn vapour inhalation.This may be attributed to immunotoxic effects of Cn on Tcells mediated macrophage functions.