Kinins and kinin receptors: importance for the activation of leukocytes

In this article, we analyzed the role of kinins and kinin receptors with respect to the acti- vation of leukocytes. In these cells, the biological effects of kinin peptides are mediated by kinin receptor subtypes B 1 ,B 2, or both, depending on species and cell type. In contrast to the other leu- kocytes, neutrophils contain the complete system for the synthesis and release of bioactive kinins. Consequently, very high concentrations of these peptides can be reached in the close neighborhood of the kinin receptors, in particular at the site of inflammation. Kinins are responsible for many ef- fects in leukocytes including the release of other inflammatory mediators, such as cytokines, pros- taglandins, leukotrienes, and reactive oxygen spe- cies. Obviously, the potency of kinins to stimulate leukocytes is dependent on the differentiation and especially on the activation stage of these cells. An upregulation of kinin receptors on neutrophils and macrophages appears to be involved in increasing the sensitivity of these cells to kinins at the site of inflammation. J. Leukoc. Biol. 68: 587-592; 2000.