Remote Screening for Optic Nerve Cupping Using Smartphone-based Non-mydriatic Fundus Photography.

PRE[COMBINING ACUTE ACCENT]CIS:: Evaluation of non-mydriatic fundus photographs captured with a low-cost, smartphone-based camera facilitated remote screening of patients for enlarged optic nerve cup-to-disc ratio in the Independent Nation of Samoa, an underserved setting with one full-time ophthalmologist in the entire country. PURPOSE To investigate factors that impact inter-rater agreement of glaucoma suspect optic disc status using a low-cost, handheld non-mydriatic fundus camera. METHODS Color fundus photographs were obtained using the PanOptic iExaminer attached to an iPhone 6S by a lay examiner on 206 participants in the Independent Nation of Samoa. Images were remotely graded by an ophthalmologist and optometrist and images from participants identified as at-risk for glaucoma were escalated to a glaucoma subspecialist for review. Fundus photo brightness, contrast, and focus were measured using the cup, rim, and temporal regions of the disc. Stereoscopic image pairs were subsequently generated from a subset of individual non-mydriatic photographs. RESULTS Features suggestive of glaucoma based on optic disc cupping were identified in 16.0% (33/206) of participants. There was moderately strong agreement between graders (90.3%) with k=0.53 (95% CI=0.33-0.73). The intra-class correlation coefficients for the cup-to-disc ratio and its difference were 0.84 (95% CI=0.81- 0.87) and 0.68 (95% CI=0.59-0.75). Of the 33 participants identified, 94% had clinical risk criteria for potential glaucoma when reviewed by a subspecialist. Color fundus photograph cup brightness was significantly associated with cup-to-disc (CDR) grade, R=0.36 (P<0.001) in which a brighter disc yielded a higher CDR. CONCLUSIONS Smartphone-based screening is a simple, low-cost method capable of measuring the CDR of the optic nerve. When combined with testing for other glaucoma risk factors such as intraocular pressure, this method of measuring CDR may help identify those patients who should be referred for further ophthalmologic assessment. We are currently conducting studies to assess the sensitivity and specificity of smart phone-based remote screening.