Effects of three-dimensional conformal radiotherapy combined with different chemotherapy in treatment of post-operative malignant glioma

Aim:To investigate the efficacy and safety of three-dimensional conformal radiotherapy combined with different chemotherapy in the treatment of post-operative malignant glioma.Methods:A total of 68 postoperation patients with malignant glioma were collected,among whom,21 accepted performed three-dimensional conformal radiotherapy alone(RT group),24 accepted nimustine interstitial chemotherapy combined with RT(ACNU+RT group) and 23 accepted temozolomide chemotherapy concurrent combined with RT(TMZ+RT group).All patients were followed up for observation of median survival time,and 1,2,3-year survival rates.Results:The survival rates of 1,2 and 3 years of RT group were 47.6%(10/21),23.8%(5/21)and 15.0%(3/21),and the median survival time was 11.0(18.2～7.6)months.The survival rates of 1,2 and 3 years of ACNU+RT group were 75.0%(18/24),41.7%(10/24)and 20.8%(5/24),and the median survival time was 20.0(35.4～12.20)months.The survival rates of 1,2 and 3 years of TMZ+RT group were 73.9%(17/23),43.4%(10/23)and 21.7%(5/23),and the median survival time was 21.0(33.6～12.2) months.The median survival time of ACNU+RT group and TMZ+RT group were significantly longer than that of RT group(χ2L=8.313,8.825,P0.05).Conclusion:Both ACNU+RT and TMZ+RT could be used for the comprehensive treatment of malignant glioma.