The Effect Of Aglaia Roxburghiana (W. & A.) Miq. Var. Beddomei On Experimentally - Induced Ulcers

The ethanolic extracts of aerial parts and fruits of Aglaia roxburghiana were tested in rats for their effect on gastric secretion and ulcer formation in Shay rats and aspirin-induced ulcer model. Doses ranging from 100 to 400 mg/kg of the extracts were used in the experiment. The fruit extract produced a dose-dependent reduction of the free acidity whereas, a significant reduction in ulcer score was observed for both aerial part and fruit extracts. Both the extracts also offered significant protection against aspirin-induced ulcers. Histopathological observations support the ulcer protective effect of Aglaia roxburghiana. The present results agree with the use of Aglaia roxburghiana in traditional medicine against gastric ulceration.