Warning of outbreak of important antibiotic resistance in strains of urology and nephrology wards

Abstract Klebsiella pneumonia and Proteus species are known as the most important causes of mortality in hospitalized patients. The present study aimed to identify antibiotic-resistant Klebsiella pneumonia and Proteus mirabilis isolated from the urology and nephrology wards in Baqiyatallah Hospital. A total of 100 clinical samples were collected from the nephrology and urology wards of the hospital within 6 months. The samples were transferred to the laboratory in the appropriate conditions. After the detection of the phenotypic resistant by the disk diffusion method, DNA was extracted from clinical samples and investigated for the presence of TEM and qnrA genes by universal primers. Then, data analyzed by SPSS software. The number of 37 isolates from K. pneumoniae and 36 isolates of P. mirabilis were resistant to at least one of the antibiotics of Ceftazidime and Cefotaxime. Antibiogram test results for 50 isolates of K. pneumonia indicated the highest resistance to Cotrimoxazole and the least rate was related to Imipenem. The number of isolates containing TEM and qnrA genes reported for K. pneumonia with frequency 26% and 8% and P. mirabilis with a frequency of 38% and 6%, respectively. Because of the emergence of resistant antibiotic strains in urology and nephrology wards, it is valuable to determine and report the pattern of antibiotic resistance. It is also important to change the pattern of drug administration due to the increasing frequency of ESBL-producing strains. Because the selective treatment of strains producing ESBL is Carbapenem or Aminoglycoside or Fluoroquinolones, the laboratories can recommend the appropriate medication.