The effect of pyridazine compounds on the cardiovascular system

Many natural as well as synthetic heterocylic compounds are known to have different biological activities. The pyridazine moiety is an important structural feature of many biologically active compounds and show diverse pharmacological properties. Pyridazines hold considerable interest relative to the preparation of organic intermediates and physiologically active compounds. However, some compounds bearing pyridazinone rings have been reported to be effective in different cardiovascular diseases. On the basis of the reported literature, we study here on pyridazine compounds to their different biological activities on cardiovascular system. Pyridazinones further draw our focused attention because of their easy fictionalization at various ring positions, which makes them attractive synthetic compounds for designing and development of novel pyridazinone as cardiotonic agents in future.