Building a model to precisely target the responders of a novel intermittent negative air pressure device-with mechanism definition
2020
Abstract Objective Due to the complexity of obstructive sleep apnea syndrome (OSAS), engaging patients in the right treatment poses a constant challenge. A novel oral pressure therapy device, the i ntermittent n egative a ir p ressure Sleep Therapy System (iNAP), has proven to ameliorate respiratory events for OSAS patients. However, the mode of action and the characteristics of its responders are not yet fully understood. Therefore, we have first disclosed the mechanism and provided systemic models to predict the treatment response. Methods Series of imaging studies were carried out to differentiate the anatomical features of iNAP responders versus non-responders. Compatible electroencephalography was used to evaluate sleep status during magnetic resonance imaging (MRI) assessments. Results The upper airway volume was statistically widened under the iNAP treatment while patients were naturally asleep (p Conclusions We were able to confirm the effect of the iNAP in widening the upper airway. Anatomic features that can be visually observed or obtained through X-ray films, accompanied with the resulting algorithms, were provided to facilitate physicians’ ability to predict patients’ treatment response to the iNAP with greater sensitivity and efficiency.
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