Development of New Electrophiles in Palladium/Norbornene-Catalyzed ortho-Functionalization of Aryl Halides
2019
This account focuses on our work in palladium/norbornene-catalyzed selective ortho -arylation and ortho -acylation of aryl halides. It will discuss our synthetic plan, initial design and revised strategy in the enantioselective synthesis of the rhazinal family of natural products. It also shows our efforts on the α-acylation reaction by the cleavage of various C(O)–X bonds, along with some mechanistic studies. 1 Introduction 2 Synthesis of the Rhazinal Family of Natural Products 2.1 Initial Design 2.2 Revised Strategy 2.3 Enantioselective Synthesis of the Rhazinal Family of Natural Products 3 Catalytic ortho -Acylation 3.1 Acid Chloride and Anhydride Strategy 3.2 Cleavage of C(O)–S Bond of Thioesters by Pd, Norbornene and Copper Cocatalysis 4 Decarboxylative Alkynylation 5 Conclusion
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