New Antimycobacterial S-Alkylisothiosemicarbazones

In connection with a systematic study of antimycobacterial agents against potentially pathogenic strains the series of 12S-alkylisothiosemicarbazones was evaluated forin vitro antimycobacterial activity againstMycobacterium tuberculosis, M. kansasii, M. fortuitum, two strains ofM. intracellulare and three strains ofM. avium. Quinoline-4-carbaldehyde-S-hexyl-isothiohydrazone was found to be more active against potentially pathogenic strains than isoniazide.