Clinical significance of serum S-100B protein in severe cerebral injury

ObjectiveTo investigate the value of S100B protein as a biology marker in diagnosis and prognostic after severe cerebral injury. MethodsSixtysix patients with severe head injury〔Glasgow coma scale score(GCS)≤8〕 were included in this study,venous blood samples for S100B protein were obtained as soon as possible after admission and every 24 hours thereafter for a maximum of 3～7 consecutive days. Serum levels of S100B protein were compared with outcome(Glasgow outcome scale score,GOS) after 6 months . ResultsOf 66 patients,25 patients died,mutilation in 22 patients,19 patients had a good outcome . Patients who died had significantly higher serum S100B values compared with those who survived (median 2.60 μg/L vs. 0.55 μg/L,P0.001),14 of 25 patients who died had peak S100B values of 2.00 μg/L or higher,compared with 4 of 41 surviving patients (P0.005). Conclusion S100B protein has a reliable value in diagnosis and prognostic after severe head injury.