No TRIFling Matter on STING.

STING is a crucial component of the mammalian innate immune response to microbial infection. In this issue of Cell Host & Microbe , Wang et al. (2016) report that TRIF, an adaptor of Toll-like receptors (TLRs), is essential for STING-mediated innate antiviral immunity as well as pro-protozoal responses.