Role of angiogenesis and angiogenic factors in colorectal cancer

Colorectal cancer, the second most frequent cause of death worldwide, is due to genetic changes in gastrointestinal cells Carcinogenesis depends on/is promoted/induced/initiated by/activation of oncogenes or inactivation of tumour suppressor genes. Microscopic human cancers may remain dormant for lifetime Tumor progression depends on a cascade of events during which the non-angiogenic phenotype switches to the angiogenic one. The switch promotes immediate recruitment of new blood vessel and, ultimately, tumor development.