Amyloid-β protein specific production inhibitory polypeptide

The main purpose of the present invention is to specifically inhibit the production of Aβ protein, to develop compounds comprising as an active ingredient of a therapeutic and / or prophylactic for drugs for Alzheimer's disease. Has the amino acid sequence shown any in one of SEQ ID NO: 1,13,14, or 22 to achieve the above object, a polypeptide that binds to the N-terminal region of BetaCTF, containing the polypeptide γ-secretase activity inhibitors, beta secretase activity inhibitor, a [beta] protein production inhibitor, and provides a treatment of Alzheimer's disease and / or prophylactic agent.