Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome
2015
Electron microscopy and biochemistry analyses reveal that the deubiquitinase Ubp6, in its ubiquitin-bound form, inhibits substrate deubiquitination by Rpn11, stabilizes the proteasome in a substrate-engaged conformation and interferes with the engagement of a subsequent substrate.
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