INDUCTION OF HEME OXYGENASE PRODUCES LOAD-INDEPENDENT CARDIOPROTECTIVE EFFECTS IN HYPERTENSIVE RATS

Abstract Although heme oxygenase (HO) has been suggested to be involved in the regulation of cardiovascular function through production of carbon monoxide (CO), the pathophysiological significance of HO in hypertensive organ damage remains unknown. We examined the effects of inducing HO-1 mRNA by stannous chloride (SnCl 2 ) on cardiac hypertrophy in stroke-prone spontaneously hypertensive rats ( SHR-SP Izm ). Chronic administration of SnCl2 resulted in a significant decrease in left ventricular (LV) weight/body weight ratio and LV brain natriuretic peptide (BNP) mRNA levels as a marker of cardiac hypertrophy and a significant increase in LV HO-1 mRNA levels and LV cGMP contents in SHR-SP Izm , while there was no significant change in systemic blood pressure. These results provide the first evidence that induction of HO in the heart attenuates cardiac hypertrophy in load-independent mechanism in genetically hypertensive rats.