Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities
2005
Abstract The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a – 41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H 37 Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.
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