Esomeprazole magnesium trihydrate and preparation method thereof

The invention relates to amorphous esomeprazole magnesium trihydrate, pharmaceutical compositions containing the amorphous esomeprazole magnesium trihydrate, and a preparation method of the amorphous esomeprazole magnesium trihydrate. The amorphous esomeprazole magnesium trihydrate is alpha-radiated by CuK, wherein X-ray powder diffraction pattern has broad peaks at parts that 2theta is 7+-1 degree and 18+-1 degree; according to peak intensity of broad peaks at parts that 2theta is 18+-1 degree being 100%, peak intensity ratios of the broad peaks at parts that 2theta is 7+-1 degree is larger than 50% and smaller than 100%. The esomeprazole magnesium trihydrate has advantages of high chemical and optical purity, stable properties, simple and controllable preparation method, and high yield, and is suitable for large scale production.