Pharmaceutico-physicochemical validation of Mamajjaka Ghana tablet, a potent antidiabetic medicine

Background: Mamajjaka Ghana Vati is a well-recognized herbal medicine for the treatment of Madhumeha. Instead of its attribute in Madhumeha, it was also therapeutically indicated for antipyretic, anthelmintic, hepatoprotective, and anti-inflammatory activities. Aims and Objective: The objective of the present study was to evaluate the significance of large-scale production of Mamajjaka Ghana tablet and its quality control aspect with a view of its wide range of applicability in therapeutics and ayurvedic pharmaceutical industry. Materials ad Methods: Mamajjaka Ghana tablet was prepared in four batches and the findings were scientifically recorded. In this analytical study, organoleptic and physicochemical evaluations of Mamajjaka decoction, solid aqueous extract (Ghana), and tablet were carried out. Results and Discussion: An average of 38.25 h were required for the preparation of Mamajjaka decoction. The average temperature maintained during the process was 95-100°C. The average yield of decoction was 168.75 L in all the four batches. An average of 11.67 kg of solid aqueous extract (Ghana) was obtained. A total of 46.68 kg of Ghana was obtained from all the four batches. An average of 97.93% of Mamajjaka Ghana tablet was obtained. Conclusion: The data pertaining to large-scale production will be useful for ayurvedic pharmaceutical industry populace to maintain quality, uniformity of dosage, and to sustain the batch-to-batch variation during various pharmaceutical operations, and thus the whole process is validated for 65.28 kg of Mamajjaka Ghana tablet .