An evaluation of siRNA screening in identification of targets in PTEN deficient tumor cells

Nuala McCabe,Steven M. Walker,Katarina Wikstrom,Caroline Greenan,Estelle McLean,Thomas F. DeLaney,Michelle McCarthy,Dj Cochrane,Claire Wilson,Timothy Davison,Fionnuala McDyer,Gera Jellema,Nicolas Goffard,Iain James,Timothy Harrison,Paul B. Mullan,D. P. Harkin,Richard D. Kennedy

An evaluation of siRNA screening in identification of targets in PTEN deficient tumor cells

2011

Nuala McCabe
Steven M. Walker
Katarina Wikstrom
Caroline Greenan
Estelle McLean
Thomas F. DeLaney
Michelle McCarthy
Dj Cochrane
Claire Wilson
Timothy Davison
Fionnuala McDyer
Gera Jellema
Nicolas Goffard
Iain James
Timothy Harrison
Paul B. Mullan
D. P. Harkin
Richard D. Kennedy

e13569 Background: PTEN is frequently lost in cancer cells through genetic mutation or epigenetic silencing. Loss of PTEN function has been widely reported to result in up-regulation of PI3K and co...

Keywords:

PTEN
Cancer research
Pathology
Medicine
Mutation
PI3K/AKT/mTOR pathway
epigenetic silencing
tumor cells
Cancer cell

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