EP422 After LACC trial: a single institutional study with our own data

Introduction/Background LACC trial has changed the paradigm regarding the surgical treatment of cervical cancer. This is the first prospective study performed in this field and in which a better prognosis has been observed in patients treated by laparotomy. Methodology This is a retrospective observational cohort study without a control group. Inclusion criteria Patients with stages Ia1 (with lymphovascular invasion) to IIa1 treated by hysterectomy and trachelectomy including lymphadenectomy between January 2007 and December 2018 at the Jimenez Diaz Foundation Hospital. Exclusion criteria Patients under 18 years Pregnant patients. Older than 80 years. Surgical contraindications. ECOG ≤50% and/or ASA ≥4 Parametrial involvement All patients who met the described inclusion criteria were selected and different clinical parameters were analyzed, including age, menopausal status, physical examination for assessment of parameter involvement. Likewise, anatomopathological characteristics were studied, such as histological type, tumor size, lymphovascular invasion, parametrial infiltration, nuclear grade, stromal infiltration. The disease-free interval was also studied, as well as the overall survival. Results For all the patients recruited, a total of 84 of them were included in the inclusion criteria. The average age of the patients was 46 years (Minimum 27 and Maximum 70 years). 53 patients studied were in stage IB1 (63%), 14 stage IA1 (16.6%), 12 stage IA2 (14.3%) and 5 stage IIA1 (5.9%). The disease-free survival studied has been up to> 5 years. There have been a total of 5 recurrences (Minimum 8 and maximum 40 months). Conclusion The percentage of relapse and survival is in accordance with the current data. Laparoscopic surgery presents an acceptable complication rate. It is important to highlight the number of patients with tumors smaller than 2cm and without other associated risk factors that could have been operated on by type A radical hysterectomy and thus avoid the potential adverse effects of a more extensive surgery. Disclosure Nothing to disclose.