Tanshinone II Aattenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation

// Xia Chen 1, * , Rui Wu 1, * , Yiwei Kong 1, * , Yuting Yang 1, * , Yu Gao 1 , Dandan Sun 1 , Qizhen Liu 1 , Dongjun Dai 1 , Zeyuan Lu 1 , Niansong Wang 1 , Sheng Ge 3 , Feng Wang 1, 2 1 Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China 2 Department of Nephrology, Shanghai Eighth People’s Hospital, Shanghai 200233, China 3 Department of Clinical Nutrition, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China * These authors contributed equally to this work Correspondence to: Sheng Ge, email: gesheng607@126.com Feng Wang, email: zyzwq1030@163.com Keywords: tanshinone, kidney, diabetes Received: January 25, 2017      Accepted: March 02, 2017      Published: March 29, 2017 ABSTRACT Oxidative stress and inflammation have been demonstrated to be involved in the onset and promotion of diabetic nephropathy (DN).Tanshinone IIA (Tan) possesses both antioxidant and anti-inflammatory properties. Here, the aim of the present study was to explore whether Tan could attenuate renal damage in the rats with streptozotocin (STZ)-induced diabetes and its potential mechanisms. Tan was gavaged to STZ-induced diabetic rats at the dose of 10mg/kg once a day for 12 weeks. Tan treatment significantly attenuated albuminuria and renal histopathology in diabetic rats. Besides, Tan treatment also effectively inhibited oxidative stress and inflammatory reaction in the kidneys of diabetic rats. Our study provided evidence that the protective effect of Tan on diabetes-induced renal injury is associated with inhibition of oxidative stress and inflammation. Tan may be a potential candidate for the treatment of DN.