Ki67 and P53 expression in breast cancer and their correlation with clinicopathological parameters

Introduction: Breast carcinoma is the most common malignancy in females and is a leading cause of death. Treatment depends upon various pathological and prognostic markers like lymph node status, size, type and grade of the tumour which influences the outcome of breast cancer. Markers like Ki-67 and p53 have been studied extensively and their roles in breast cancer are yet to be established. We evaluated the expression of Ki67 and P53 in breast cancer and their association with other clinico-pathological factors was studied. Materials and Methods: Ki67 and P53 expression was assessed in 60 breast cancer cases admitted to our hospital over a period of one year. Association with other prognostic parameters was evaluated. Statistical analysis was done by Chi square test and a p value of Results: 43.33% cases had low proliferative Ki-67 score whereas 56.67% of the cases were highly proliferative. p53 expression was seen in 41.66% cases. Ki-67 and p53 expression were not significantly related to age, menopausal status, and tumour size whereas a significant correlation was seen with positive axillary lymph node status, high histological grade, negative hormone receptor status (ER, PR) and positive HER2/neu expression. Significant association was seen between Ki-67 and p53 expression. Conclusion: Ki67 and P53 may be considered as a valuable biomarker in breast cancer patients which can help in planning treatment strategies.   Keywords: Breast cancer, Clinicopathological parameters, Ki 67, P53.