Decreased regional honmgeneity in patients with poststroke depression： a resting-state functional magentic resonance imaging study

Objective To investigate the characteristics of resting-state functional magnetic resonance imaging （fMRI） in patients post-stroke depression （PSD）. Methods Resting-state fMRI scans were performed in 13 patients with and without post-stroke depression. A regional homogeity （ReHo） approach was used as an indicator. The brain function was analyzed in patients with post-stroke depression.Results Compared to a control group, the ReHo values decreased significantly in a PSD group in the left middle frontal gyms, right superior frontal gyms, right middle frontal gyms, right anterior cingnlate gyms, right posterior cingutate gyms, left insular lobe, left caudate nucleus, and left hippocampus. Conclusions The patients with PSD had restingstate neural circuit dysfimction, suggesting that the need to focus on the emotional state of stroke patients in the clinical treatment process. Key words: Stroke;  Depression;  Magnetic Resonance Imaging