Absolute bioavailability, mass balance, elimination route, and metabolite profile of the selective oral MEK1/2 inhibitor pimasertib in cancer patients.
2014
e13552 Background: The MAPK signaling pathway is aberrantly upregulated in cancer. Pimasertib is a selective, uncompetitive MEK1/2 inhibitor with potent activity in human melanoma cells and xenogra...
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