Visualization of blood flow in brain tumor in small animal with ultrafast ultrasound

How to precisely evaluate the characteristics of glioma tumor in vivo is a challenging question for surgical resection clinically. Due to the infiltration feature of the tumor, precise resection remains challenging because of the uncertainties of surrounding vasculature. The sensitivity of flow measurement is improved by ultrafast plane-wave imaging which is capable of delineating the flow information in the brain. In this study, we first time visualize the blood flow distribution of glioma tumor in a small animal with plane-wave Doppler ultrasound imaging method, yielding highly resolved neurovascular map of the glioma.