Imaging Hypoxia in Orthotopic Rat Liver Tumors with Iodine 124–labeled Iodoazomycin Galactopyranoside PET

Christopher C. Riedl,Peter Brader,Pat Zanzonico,Yun Shin Chun,Yanghee Woo,Paramjeet Singh,Sean Carlin,Bixiu Wen,C. Clifton Ling,Hedvig Hricak,Yuman Fong

Imaging Hypoxia in Orthotopic Rat Liver Tumors with Iodine 124–labeled Iodoazomycin Galactopyranoside PET

2008

Christopher C. Riedl
Peter Brader
Pat Zanzonico
Yun Shin Chun
Yanghee Woo
Paramjeet Singh
Sean Carlin
Bixiu Wen
C. Clifton Ling
Hedvig Hricak
Yuman Fong

Autoradiographic analysis of the regions of high iodine 124–labeled iodoazomycin galactopyranoside uptake were shown to correspond to regions of intense pimonidazole and EF5 immunohistochemical staining, demonstrating that this tracer colocalizes with markers known to concentrate in tissue hypoxia.

Keywords:

Pimonidazole
Iodine
Iodine Radioisotopes
Positron emission tomography
Pathology
Hypoxia (medical)
Liver tumor
Medicine
Immunohistochemistry
rat liver

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