Au nanochannels technique and its application in immunoassay

Au nanotubules (channels) can be electrolessly plated within the pores of polycarbonate microporous filtration membranes. When an electric field was applied on the cell consisting of the membrane and Pt electrodes, the response current decreased due to a baffle effect from big molecules when the electrolyte ion and big molecules passed through the channels modified with chemical groups. Based on this principle, a nanotubules-based sensing technique has been developed. This method can be applied to the determination of human IgG.with a detection limit of 0.34 ng/mL.