Mutilin derivatives use as a pharmaceutical.

Compound of formula ** ** Fomula wherein T is (1-6C) cycloalkyl- (1-6C) alkyl, mono- or dialkylamino (1-6C) cycloalkyl- (1-6C) alkyl), acylamino (C1-6) cycloalkyl- (1-6C) alkyl, hydroxy (C1-6) alkyl, guanidino-imino (C1-6), ureido-imino- (C1-6 alkyl) thioureido-imino- (C1-6) isotioureido- imino (C1-6) acyloxy (C1-6) cycloalkyl- (C1-6) benzoyloxyalkyl or (C1-6); and wherein the phenyl ring is optionally further substituted with up to four groups independently selected from halogen, (1-6C) alkyl, aryl, aryl (1-6C) alkoxy (1-6C) alkoxy (1-6C) cycloalkyl- (C1-6), (C1-6) haloalkyl, arylalkoxy (1-6C), hydroxyl, nitro, cyano, azido, acyloxy, carbamoyl, mono or di-N-alkyl (C1-6) carbamoyl, alkoxy (C1-6) alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, (C1-6) guanidino, amidino, (C1-6) amidino, sulfonylamino, aminosulfonyl, alkylthio (1-6C) alkyl, (C1-6 ) alkylsulphinyl, (1-6C) alkylsulphonyl, heterocyclyl, heteroaryl, heterocyclyl (C1-6) alkyl and heteroaryl (C1-6), or two adjacent carbon atoms of the ring may be linked via an alkylene chain (C3- 5) to form a carbocyclic ring; or T is (CH2) n-XR1 wherein n is 1 to 6; X is oxygen or NR2 wherein R2 is hydrogen or (1-6C) alkyl, or hydroxy (C1-6) alkyl or (1-6C) cycloalkyl- (1-6C) alkyl, R1 is hydrogen or alkyl (C1-6) alkyl, (C1-6) mono- or dihalo, amino (C1-6) alkyl, hydroxy (1-6C), phenylalkyl (1-6C) alkyl, (1-6C) furanilalquilo (C1 -6), (3-6C) cycloalkyl, and the corresponding ammonium salts, or R1 and R2 together with the nitrogen atom to which they are attached form a 5- to 7 members containing at least one nitrogen atom, or XR1 is piperazinyl or morpholinyl.