Association between coronary artery disease (CAD) and heart failure and age in obstructive sleep apnoea (OSA) patients

Cardiovascular diseases are most frequent complications of untreated OSA. The aim of this study was to compare OSA pts with CAD and without CAD. We studied 1048 OSA pts with moderate or severe disease (AHI - 42.1±21), mean age - 56.1±10.4 years, BMI - 34.4±6,4 kg/m 2, Epworth score - 11.3±5.8 points, mean SaO2 -90.6±5.8%. We found 812 pts without CAD (77.5%; group 1) and 236 pts with CAD (22.5%; group 2). Comparison of both groups is shown in table. View this table: Logistic regression analysis revealed that: heart failure (OR- 4.43; 95%CI – 2.74-7.15; p 60 vs ≤ 60 years (OR- 2.38; 95%CI – 1.82-3.12;p 125 vs ≤ 125 pg/ml (OR – 1.84; 95%CI – 1.27-2.67; p=0.001) and diabetes (OR-1.47; 95%CI – 1.007-2.14; p=0.045) were independent predictors of CAD after adjusting for AH, stroke, AF, COPD, BMI > 30 vs ≤30 and hyperuricaemia. Conclusions: Coronary artery disease was frequent in OSA pts (more than 20%). We found strongest association between heart failure and age and CAD in OSA patients.