Частота анеуплоидии в сперматозоидах при нормозооспермии и при бесплодии, связанном с патозооспермией

FISH-analysis of sperm aneuploidy for chromosomes 13, 18, 21, X and Y was performed fertile normozoospermic men and infertile pathozoospermic men. The frequency of aneuploidy in pathozoospermic men twice exceeds the frequency of aneuploidy among normozoospermic men. A statistically significant difference between these groups was found the frequency of dysomies 13 and 18 (p=0.03 and p=0.01, respectively), nullisomies 13 and 21 (p=0.02 and p=0.03, respectively) and XY dysomy (p=0.01).