Pharmacological and Hemodynamic Profile of Nebivolol,*a Chemically Novel, Potent, and Selective β1-Adrenergic Antagonist

Summary:The pharmacological profile of nebivolol (N), a chemically novel β-adrenergic antagonist, was assessed in investigations on isolated tissues, awake spontaneously hypertensive rats (SHR), closed-chest anesthetized dogs, and humans. In vitro, N was found to be a potent antagonist of β1-adrener