Protective effect of exogenous 8-oxo-2′-deoxyguanosine on Drosophila melanogaster larval stages under heat shock

Abstract The influence of exogenous 8-oxo-2′-deoxyguanosine on the development of Drosophila melanogaster under normal conditions, and under the influence of short-term heat shock was studied. It was shown that 8-oxo-2′-deoxyguanosine was not toxic at concentrations of up to 1 μM. A tendency to accelerate larval development and fly emergence was observed under the influence of this compound in our experiments. Short-term heat shock causes a 50–80% decrease in the number of larvae that complete development. The addition of exogenous 8-oxo-2′-deoxyguanosine to the food before thermal influence negates this effect and brings the levels of the imago emergence indicators back to the basal level. The obtained results are further evidence of the possible bioregulatory and adaptogen functions of 8-oxo-2′-deoxyguanosine.