Hypertension superimposed on type II diabetes in Goto Kakizaki rats induces progressive nephropathy

disease (ESRD) in patients with type II diabetes has Background. Type II diabetes in the Goto Kakizaki (GK) been observed in recent years. Diabetic nephropathy, rats (derived from Wistar rats) is not associated with the develmainly due to type II diabetes, is now the leading cause opment of obesity, hyperlipidemia, hypertension, or pronounced renal functional changes. The aim of this study was of ESRD in the United States, Japan, and Europe [1–3]. to investigate the effect of superimposed hypertension on renal However, the pathogenesis of nephropathy associated function and morphology under conditions of hyper- and nor- with type II diabetes is still not fully understood. While moglycemia. nearly 90% of all diabetics suffer from type II diabetes, Methods. The evolution of biochemical and morphologic renal changes was examined in GK and Wistar rats treated only 20% to 50% of patients with type II diabetes dewith deoxycorticosterone acetate (DOCA) salt over 24 weeks. velop nephropathy after 20 years of diabetes, depending